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An unexplained disease ravages the world, impairing the communicative abilities of all humans in a variety of ways. The most impacted have impaired cognitive function and are prone to violence. The less impacted can lose their ability to read or speak. At the end of the story, it is revealed that two children are able to speak fluently.

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After humans make their way into space, military outposts are frequently attacked by an alien race who communicate using a language dubbed "Babel-17". Rydra Wong is enlisted to interpret the messages, soemthing which fundamentally changes her.

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Rydra would likely be chased by the zombie-like people most affected by the plague, as these people beome violent towards less affected people.

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Since Rye is still able to speak and understand spoken language, she should be able to communicate with the people she comes across. Once her story spreads, Rydra will surely want to speak to her.

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Rye would find Rydra hiding from the people trying to fight her, as Rydra knows she is outnumbered. Rydra could help Rye teach the kids, as well as read the minds of the diseased. Maybe the severely affected have some knowledge which could help cure the effects of the plague?

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When Rydra catches Rye up on what she knows about Babel-17, Rye would use her experiences with the plague to show how communication between different languages can be achieved, even without fully understanding each others forms of communication. Just as she communicated with Obsidian, there must be a way for understanding and communication with the speakers of Babel-17.