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Explain how the ideas, beliefs, and cultures of colonists influenced the development of regional differences.

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While the Northern colonies were focused on religion, the Southern colonies were focused on economy. This, along with different approaches to native Americans led to the development of regional differences.

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Virginia was founded for purely economic reasons. Had the Headright system and tobacco, which made money for colonists and lead to expansion.

Maryland was founded by the Calverts (Lord Baltimore) as a a real estate venture and colony for English Catholics. Maryland ended up accepting Protestants and drafted the Toleration Act, assuring Catholics religious freedom.
Both colonies had conflict with Native Americans.

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Quakers and William Penn founded Pennsylvania and Philadelphia. He wanted Pennsylvania to be profitable as well as a haven for Quakers and many other religious groups. He gave Indians compensation for their land.

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Separatists (Pilgrims) fled England for the United States and founded Plymouth.
Puritans settled in Massachusetts Bay in 1629, and aimed to build a "city upon a hill" as an example for the rest of the New World. Massachusetts was a theocracy with little separation of church and state. There was no religious freedom. People who disagreed with Puritans were banished, such as Thomas Hooker who founded a colony in Connecticut and Roger Williams who wanted separation of church and state and founded Rhode Island (the only colony for a time that allowed complete religious freedom).
New England was more tolerant of Natives.

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North: Mostly religious freedom
Middle: mix of religious freedom and economics
South: Economics

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Georgia was founded by James Oglethorpe as a border against Spanish and a place for the poor/debtors. Georgia instituted slavery and plantations

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This depiction shows the Pilgrims practicing their religion on the shore of Plymouth.

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Maryland was founded by the Calverts (Lord Baltimore) as a a real estate venture and colony for English Catholics. Maryland ended up accepting Protestants and drafted the Toleration Act, assuring Catholics religious freedom.

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https://www.youtube.com/watch?v=v3DrVe-MuPQ