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Stratum Corneum

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3 different names: Stratum Basale, Basal Layer, & Stratum Germinativum

Stem cells are contained here

Mitosis takes place here

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1st) Epidermis, superficial layer, free nerve endings are present and that's why it hurts, such as a sunburn

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Inflammatory
Blood clots form and wbc’s moved to the damaged areas to get rid of pathogens and other bacteria

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2nd) Dermis and Epidermis, blisters but not everything is damaged, sensory receptors are still "alive" so they can transmit pain, hair follicles and sweat glands can still be intact

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Migratory:
-Epithelial cells "migrate" across surface of the wound
-In the dermis: fibroblasts begin to lay down collagen

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Proliferative
-the dense irregular CT is replaced by granulation tissue (scar tissue), in which collagen is more dense w/less blood vessels

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Maturation phase
-Scab is formed and falls off

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3rd) Nerve cells/receptors are destroyed and epidermis, dermis and epidermal derivatives are affected, nearly no pain or no pain at all

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Keratinocytes, Melanocytes, & Merkle cells are here

Has a flexible membrane

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- consists of dense irregular connective tissue
- has blood vessels, glands, hair follicles
- abundant in collagen and has elastic fibers
- supports accessory structures of integument and provides strength and elasticity

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Keratin begins to be laid down to create Lamellar granules

Keratinocytes begin to lose nuclei & organelles

Water-repellent layer starts

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- areolar (loose) connective tissue
- has capillary loops for epithelium
- dermal papillae (attaches dermis to epidermis)
- increase surface area of contact between epidermis and dermis

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Only present in thick skin

Contains the protein eleidin (lipid-rich protein to help reduce friction)

2-3 cells thick

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Apical layer

Water resistant

Cells here are flattened, dead, and interlock