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Leonardo da Vinci, the quintessential Renaissance man, is born in Vinci, Italy. He would become one of the most versatile geniuses in history, excelling in art, science, and engineering.

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Michelangelo Buonarroti is born in Caprese, Italy. He would grow to become a master sculptor, painter, architect, and poet, creating some of the most iconic works of the Renaissance.

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Raffaello Sanzio da Urbino, known simply as Raphael, is born in Urbino, Italy. He would become famous for his paintings and frescoes, particularly his work in the Vatican.

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1490: Leonardo da Vinci paints 'Lady with an Ermine'

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1490: Leonardo da Vinci paints 'Lady with an Ermine'

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This portrait, one of only four paintings of women by Leonardo, showcases his mastery of sfumato technique and psychological insight.

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1495-1498: Leonardo da Vinci paints 'The Last Supper'

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1495-1498: Leonardo da Vinci paints 'The Last Supper'

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Leonardo creates this iconic mural in the refectory of Santa Maria delle Grazie in Milan, revolutionizing the depiction of perspective and emotion in religious art.

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Michelangelo carves his colossal marble statue of David, which becomes one of the most recognizable works of Renaissance sculpture.

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1503-1506: Leonardo da Vinci paints the 'Mona Lisa'

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1503-1506: Leonardo da Vinci paints the 'Mona Lisa'

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Leonardo creates his most famous painting, the 'Mona Lisa', known for its enigmatic smile and innovative techniques.

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1508-1512: Michelangelo paints the Sistine Chapel ceiling

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1508-1512: Michelangelo paints the Sistine Chapel ceiling

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Michelangelo spends four years painting the ceiling of the Sistine Chapel, creating one of the most significant works of High Renaissance art.

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1509-1511: Raphael paints 'The School of Athens'

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1509-1511: Raphael paints 'The School of Athens'

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Raphael creates this masterpiece fresco in the Apostolic Palace in the Vatican, depicting the greatest mathematicians, philosophers and scientists from classical antiquity.

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Raphael works on his last painting, 'Transfiguration', which is considered by many to be his masterpiece. It remained unfinished at his death in 1520.

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Leonardo da Vinci dies in Amboise, France, leaving behind a legacy of groundbreaking art and scientific studies that continue to influence the world today.

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Michelangelo dies in Rome at the age of 88, having transformed the world of art with his sculptures, paintings, and architectural designs.