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Hastings, C. (2023, November 9). Magnetic dressing improves diabetic wound healing |. Medgadget. https://www.medgadget.com/2023/11/magnetic-dressing-improves-diabetic-wound-healing.html

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Hastings , C. (2023, March 30). Smart Bandage Monitors and Treats Chronic Wounds. Medgadget . https://www.medgadget.com/2023/03/smart-bandage-monitors-and-treats-chronic-wounds.html

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Bi-polymer based wound dressings with drugs, biomacromolecules, and cells that are cytocompatible, hemostatic, initiate skin rejuvenation and rapid healing, and possess anti inflammatory and antimicrobial activity (N. Raju et al., 2022).

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Raju, N. R., Silina , E., Stupin , V., Manturova , N., Chidambaram, S. B., & Achar, R. R. (2022, July 28). Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414988/

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Derakhshandeh, H., Kashaf, S. S., Aghabaglou, F., Ghanavati, I. O., & Tamayol, A. (2018, December). Smart bandages: The Future of Wound Care. Trends in Biotechnology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511580/

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1. Nithya Rani Raju:

Division of Biochemistry, School of Life Sciences, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, India; ni.ude.inussj@rinarayhtin

2. Ekaterina Silina:

Institute of Biodesign and Modeling of Complex Systems, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya Street 8, 119991 Moscow, Russia; ur.liam@aniretakeanilis

3. Victor Stupin:

Department of Hospital Surgery No 1, N.I. Pirogov Russian National Research Medical University (RNRMU), Ostrovityanova Street 1, 117997 Moscow, Russia; ur.kb@rotcivts

4. Natalia Manturova:

Department of Plastic and Reconstructive Surgery, Cosmetology and Cell Technologies, N.I. Pirogov Russian National Research Medical University, Ostrovityanova Street 1, 117997 Moscow, Russia; ur.xednay@ilatanavorutnam

5. Saravana Babu Chidambaram:

Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, India; ni.ude.inussj@c.ubabanavaras

6. Raghu Ram Achar:

Centre for Experimental Pharmacology and Toxicology (CPT), Central Animal Facility, JSS Academy of Higher Education & Research, Mysuru 570015, Karnataka, India

Correspondence: ni.ude.inussj@ayrahcarr; Tel.: +91-9535413026

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1. Hossein Derakhshandeh:

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.

2. Fariba Aghabaglou:

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.

3. Ian Ghanavati:

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA.

4. Ali Tamayol:

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68508, USA. (900 N16th Street, Room NH W332, Lincoln, NE, 68508; Tel: (402) 472-1601, ude.lnu@loyamata, Twitter: @lab_limb)

5. Sara Saheb Kashaf:

The University of Chicago Medical Scientist Training Program, Pritzker School of Medicine, University of Chicago, Chicago, Illinois, USA.

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July 28, 2022

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"Smart Bandage"

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Adi. (2015). Smart Bandage . SMART BANDAGES THE LATEST WEARABLE HEALTHCARE INNOVATION. The Horizons Tracker . Retrieved February 19, 2024, from https://adigaskell.org/2015/04/07/smart-bandages-the-latest-wearable-healthcare-innovation/.

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Chronic and acute wounds are seen on a daily basis within the healthcare system. Over time, wounds can become increasingly worse due to additional patient comorbidities which can include: age, smoking, gender, nutrition, obesity, disease conditions, and immunosuppressive medications. Even with patient's medical issues, what dressings can we use to support increased healing times and promote anti-inflammatory processes?

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Introduction:

Throughout the research article, the authors studied different dressings, applications of dressings, key findings, and pros and cons of each.

The main goal in wound healing is to mimic characteristics of fetal tissue regeneration in the adult healing phase, including complete hair and glandular restoration without delay or scarring (N. Ranju et al., 2022).

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Study Findings:

A smart and multifunctional dressing material must be applied based on the wound type. Some things that need to considered when choosing the ideal dressing for optimal wound healing:

1. the proficiency to establish a damp environment

2. to facilitate movements in the epidermis

3. to encourage blood vessel formation and tissue regeneration

4. to provide good permeability for oxygen and water vapor

5. to ensure a decent heat in the wound site to stimulate the circulation of blood

6. to be easily removed

7. to encourage debridement and to promote leukocyte movement and enzyme build-up

8. sterile, non-toxic, and allergy free

9. biocompatible and effective drug administration

10. high absorption potential for wound exudates

Wound dressings today come in many shapes and sizes and include hydrogels, gauze, foams, films, topical formulas, and nanofiber composites.

Hydrogels:

Wounds leaking little to none

Painful/necrotic wounds

Pressure ulcers and donor sites

Second degree burns

Infected wounds

Film:

Partial-thickness wounds

Donor sites and lacerations

Stage I and Stage II pressure ulcers

Sponge:

Venous diabetic ulcers

Tunneling wounds with heavy exudate

Tracheostomy and Gastrostomy tubes

Foam:

Minor burns and skin grafts

Pressure and diabetic ulcers

Draining peritoneal wounds

Tracheostomy and Gastrostomy tubes

Gauze:

Infected wounds

Wounds that require packing

Frequent dressing changes

Nanocomposite:

A wide variety of wounds depending on the combination dressing

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Conclusion:

Multifunctional dressings investigation focuses primarily on those that encapsulate bioactive substances, sustain drug release, are stimuli sensitive, homeostatic, and have plenty of other prospects for clinical benefits. Some of these products do not release biologicals that directly enhance the healing process. These studies can be considered viable to come extent. Despite the emergence of multiple trials with abundant treatments, there is a lack of high-quality evidence (N. Raju et al., 2022).

Emerging treatments based on biomaterials, nanoparticles, and proteases with biomimetic properties hold much potential for improving wound care and will be a valuable addition to the therapeutic toolbox for treating slow-healing wounds (N. Raju et al., 2022).

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Reference for Study Findings:

Raju, N. R., Silina , E., Stupin , V., Manturova , N., Chidambaram, S. B., & Achar, R. R. (2022, July 28). Multifunctional and Smart Wound Dressings—A Review on Recent Research Advancements in Skin Regenerative Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9414988/

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Introduction:

Chronic non-healing wounds is a major challenged faced today in healthcare and affect a large number of people, serving as a financial burden, and is a leading cause of limb amputation (H. Derakhshandeh et al., 2018).

Wound care technology should:

1. Create a moist, clean, and warm environment

2. Protect the wound bed from mechanical trauma and bacterial infiltrations

3. modulate exudate level

4. allow for gas exchange

5. promote thermal insulation

6. be non-toxic and non-allergenic

7. deliver therapeutic compounds essential for healing with optimal temporal profile

It is expected that the next generation of multifunctional "smart" dressings will lead to a paradigm shift in wound care (H. Derakhshandeh et al., 2018).

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Study Findings:

These authors and researchers have found that the need for smart bandages in wound care has increased drastically over time. Limitations of current wound care technologies have been found and include:

correct utilization of antibiotics where improper and prophylactic use can lead to the development of antibiotic-resistant bacteria

increased cost of treatment and visits for wound cleaning/redressing increase

inability to provide data about the status of the wound bed and its healing rate

wound care dressings are passive and cannot actively respond to variations in the wound environment

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Dressings with integrated sensors can provide important information that could expedite decisions, reduce healthcare costs and time of hospitalizations.

pH Sensors:

Elevated pH in wound bed is a sign of infection

Temperature:

provides information such as healing, infection, and inflammation in the wound bed

Oxygen:

Hypoxia may be detrimental to the healing process and can indicate rate of angiogenesis

Moisture:

Reduces inflammation and enhances proliferative phase of dermal repair and rate of revascularization compared to dry wound conditions

Mechanical and Electrical:

change in response to skin disorders or diseases as well as during the healing process

Enzymes:

the up or down regulation of enzyme levels can indicate abnormalities

Active Drug Release:

Enable the precise control of temporal or even spatial release profile and release drugs in response to external stimulation that drives the drug toward the wound bed.

Automated Wound Dressings:

systems that can sense and interpret data and decide on the delivery of therapeutics

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Conclusions:

There is a continually growing number of chronic wounds from diabetic patients, burns, pressure ulcers, and other wounds. To aid in the advancement of affected patients, healthcare has put forth substantial efforts to develop more effective therapies to enhance wound bed healing.

Recent developments in the field of flexible and wearable electronics had brought forth a new generation of wound dressings that help understand the wound conditions or the interface of tissue healing.

Smart systems, which sense, respond, report, or a combination of these, can address many of the challenges associated with wound healing, particularly for chronic wounds.

Smart systems may also promote better wound management, improving clinical outcomes by means such as detecting infection in a timely manner or providing alerts for patients.

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References for Study Findings:

Derakhshandeh, H., Kashaf, S. S., Aghabaglou, F., Ghanavati, I. O., & Tamayol, A. (2018, December). Smart bandages: The Future of Wound Care. Trends in Biotechnology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511580/

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September 6, 2018

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Reuters. (2021, December 1). Singapore tests out “smart bandage” for remote recovery. YouTube. https://www.youtube.com/watch?v=U80gvOzoeRo 

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Singapore tests out 'smart bandage' for remote recovery

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Reuters. (2021, December 1). Singapore tests out “smart bandage” for remote recovery. YouTube. https://www.youtube.com/watch?v=U80gvOzoeRo

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Data sent to clinician and/or patient regarding

Fever

Infection

pH level

Hypoxia

Moisture level

Increase or decrease in enzyme level

Widely applicable with multifunctional aspects

Simple for clinicians to use

Patient can receive antibiotic treatment without direct clinician administration

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Cannot be used for heavily bleeding wounds

More expensive

Difficult to store

Less choice/flexibility in indications for use

Needs a stable and strong power source/sensors and reliable networks for data management and rely on multifaceted research activities

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I believe that integrating a "smart bandage" into practice would be greatly beneficial to patients, as well as clinicians. It would offer clinicians a quicker and more direct way of treating chronic wounds over time. These bandages would also give a clinicians and patients a quicker response time to receiving treatment for wounds based on pH colors, moisture level, enzyme accumulation, etc., before the wound progression got too far.

Although I think this would be immensely beneficial, researchers and developers still have a lot of work to do in making these "smart bandages" affordable and a first line of defense against chronic non-healing wounds.

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Input

I like to accumulate all available data, information, and ideas to assist others when needed.

Learner

I have a desire to learn and continuously improve.

Achiever

I work hard at whatever task is at hand and like to be busy and productive throughout the day.

Discipline

I like to have structure and routine in any event. Everything should be planned and timed accordingly.

Consistency

I thrive in stable routines and clear rules/procedures.

I also believe in "The Golden Rule," and try to maintain a good relationship between colleagues.

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1. Matthew (Maximizer)

Matthew's strength would stimulate excellence within our presentation. With him being a perfectionist and success, he would push the group to be the best and ultimately make an amazing leader for the group.

2. Pablo (Positivity)

I chose Pablo to add enthusiasm and to get people excited. With a big project, we need a bright outlook and optimistic person on our side. This will help with overall morale on the team.

3. Sheila (Strategic)

Sheila would help the team create alternative way to present ideas and data. She would be able to help spot relevant patterns and issues with the presentation.

4. Carlos (Context)

Carlos would use his knowledge of past, present, and future data/information to ensure that the research would help advance the field of study and aid with future research as well.

5. Isabelle (Includer)

I chose Isabelle to aid in this presentation to include and incorporate all member of the team into the presentation process. I believe she would make a great team member for delicating and maintaining work ethic within the team.

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I chose all of these team members because they do not share the same strengths as I do. I believe that with a wide array of strengths, the team will be able to look at information differently and have different perspectives that would be helpful and generate a new way of thinking among others.