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He was the son of Sir Mattew Carew, master in chancery, and his wife Alice, daughter of Sir John Rivers, Lord Mayor of the City of London and widow of Ingpen. The poet was probably the third of the eleven children of his parents, and was born in West Wickham in London

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Merton College, Oxford. He took his degree of B.A. early in 1611 and proceeded to study at the Middle Temple. Two years later his father complained to Sir Dudley Carleton that he was not doing well. He was therefore sent to Italy as a member of Sir Dudley's household and, when the ambassador returned from Venice, he seems to have kept Thomas Carew with him, for he was working as secretary to Carleton, at the Hague, early in 1616. However, he was dismissed in the autumn of that year for levity and slander; he had great difficulty in finding another job.

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Poems. By Thomas Carew, Esquire is a collection of lyrics, songs, pastorals, poetic dialogues, elegies, addresses, and occasional poems. Most of the pieces are fairly short—the longest, "A Rapture," is 166 lines, and well over half are under 50 lines. The subjects are various: a number of poems treat love, lovemaking, and feminine beauty. Several of the poems, including "An Elegie upon the death of the Deane of Pauls, Dr. John Donne" are memorial tributes; others, notably "To Saxham," celebrate country-house life; and a few record such events as the successful production of a play ("To my worthy Friend, M. D’Avenant, upon his Excellent Play, The Iust Italian") or the marriage of friends ("On the Marriage of T. K. and C. C. the Morning Stormie"). Many of the songs and love poems are addressed to the still-unidentified "Celia," a woman who was evidently Carew's lover for years. The poems to Celia treat the urgency of courtship, making much of the carpe diem theme. Others commend Celia through simile, conceit, and cliché.

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Was died in 1639 in London