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The Spanish conquistador Hernando Cortes lands on the coast of Mexico with 600 men, 16 horses and about 20 guns

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After a little more than a year Cortes recaptures Tenochtitlan and finally establishes Spanish control over Mexico

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Francisco Pizarro sails from Panama to attempt the conquest of Peru

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The Spanish conquistadors capture and sack the Inca capital of Cuzco, high in the Andes

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With the end of the siege of Cuzco, and the flight of Manco Inca, the Spanish have full control of Peru

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Venezuela, Colombia and Ecuador become the Spanish viceroyalty of New Granada, with Bogota as the capital