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CRISPR (clustered regularly interspaced short palindromic repeats)-based gene editing

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CRISPR (clustered regularly interspaced short palindromic repeats)-based gene editing

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Gene therapy that can modify genes for therapeutic reasons (Davis, 2012). A personalized CRISPR therapy (on demand) was developed and delivered this past year, with no adverse effects. This will pave the way for on demand gene therapies in the future for rare genetic diseases (Murdock, 2025). The patient who received the CRISPR therapy this past year is an infant with a genetic mutation causing a CPS1 (carbamoyl phosphate synthetase 1) deficiency. Which is an ultra-rare disease of the urea cycle that prevented him from being able to break down proteins in food. His body isnt able to excrete ammonia properly which can cause permanent neurologic damage if untreated. The only treatment prior to this would be a liver transplant.(Murdock,2025). After receiving this therapy his body has been able to tolerate protein and has needed less medication to reduce the ammonia levels. Not only this, but he has gotten over some illnesses that previously would cause an excess build up of ammonia in his body. He also has had very little side effects from this therapy. He will still need monitoring for the rest of his life, but this treatment has given him another chance at life that he previously would not of had.

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https://crisprtx.com/gene-editing/therapeutic-approach#

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https://youtu.be/UKbrwPL3wXE?si=K_2URguEsAcHg2dN

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Procision treatment that can attack the exact gene mutation

Potential cure for rare genetic diseases with no previous treatments

Potentially reduced side effects compared to other treatments

One time treatment rather than a lifetime of treatments

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Unaware of long term effects due to how new it is

Treatment could potentially be very expensive and unattainable to a lot of people

Possible technical challenges

Manufacturing complexities since its geared towards individual genomes.

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1. Empathy: This strength will help the team because it helps me to understand others feelings and what they are going through. That will help give insight on why this innovation would be beneficial for the facility.

2. Developer: This strength is all about uplifting others and helping them succeed, and this will help the team by being able to see how this innovation will benefit others and wanting to implement at our facility.

3. Harmony: This strength will help me bring the team together to make the decision on adopting this innovation.

4. Arranger: This strength will help me to execute and help put the innovation into effect.

5. Futuristic: Being futuristic allows me to imagine what the future holds and this will help the team by allowing me to explain the benefits of having this innovation in the future.

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I think this is a great innovation and will have a huge impact on the future. I believe it will give a lot of people a chance at a longer and healthier life that they previously would not of had due to lack of treatments. This also could reduce the burden on people who normally would have to receive treatment for the rest of their lives. My only concerns are we wont know the long term effects it can have on people since it's so new and this will probably end up being very costly and not available to a lot of people.

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1. Alice (achiever): She is a hard worker and go getter, and that will help our team stay productive in making the decision on adopting this innovation.

2. Carter (communication): He is good at getting points across to other people and can help with the presentation on this innovation.

3. Pablo (positivity): He will help by getting everyone excited about this innovation with his positivity.

4. Brandon (belief):He is firm on what he believes in and will help keep them team focused on this innovation.

5. Randall (responsibility): He is committed and will help keep the team aligned on what they need to do.