# data[].attributes.body
Tim Salomons - https://lepubscientifique.com/le-pub-events/

# data[].attributes.attachment_link.title
Geometric and functional organization of cortical circuits - Nature Neuroscience

# data[].attributes.attachment_link.description
Nature Neuroscience - Geometric and functional organization of cortical circuits

# data[].attributes.attachment_link.readable_text
Adelaide: Tuesday, 29 June 2021, 19:30 ACST

London: Tuesday, 29 June 2021, 11:00 BST

Amsterdam: Tuesday, 29 June 2021, 12:00 CEST

New York: Tuesday, 29 June 2021, 06:00 EDT

Wellington: Tuesday, 29 June 2021, 22:00 NZST

Check out more upcoming events - www.lepubscientifique.com

Cancellation Terms Places can be cancelled and refunded up to 48 hours before the start of the event. Within 48 hours of start time no refund.

Recordings Buy now watch later. If you buy a ticket you can either watch live or catch up later. A link to the recording will be sent out to everyone who buys a ticket.

# data[].attributes.attachment_link.title
Pain Revolution Fundraiser - Le Pub Scientifique

# data[].attributes.attachment_link.description
Welcome to the Pain Revolution First Up Ever wondered what a Pain Revolution public event looks like? We have! And we are super excited welcome Local Pain Educator, Abbie Norrish to demonstrate live how they are changing people's understanding of pain on a grand scale.

# data[].attributes.body
AU, Adelaide | ACST | July 1, 2, 3 | 06:30 – 12:00

NZ, Wellington | NZST | July 1, 2, 3 | 09:00 – 14:30

US, New York | EDT | June 30, July 1, 2 |

# data[].attributes.attachment_link.readable_text
Online Course

LIVE | INTERACTIVE | GLOBAL
Join Lorimer Moseley and his guests for this first ever global Pain MasterSession - a massive 16.5 hours of cutting-edge pain science and clinical application with 4 of the world's pain super stars. It's going to be incredible!

THE MASTER SESSION
What we know now about persistent pain puts recovery right back on the table.
Lorimer Moseley is one of the most highly regarded and sought-after pain experts on the planet today. He draws on over 30 years of clinical pain research and practice to lead you on a journey through the latest discoveries in modern pain rehabilitation.

Pain science and treatment is a fast-moving field. Discoveries from across the fundamental and applied sciences open up new and exciting opportunities for improving outcomes for those at risk of, or challenged by, persisting pain.
We love getting the science to the people who can use it the most - clinicians at the coal face.
This MasterSession will bring discoveries in pain science to life in a clinically applicable way. Contemporary learning principles and techniques will be used to guide participants through how we think, what we think, how we can optimise the impact of educational strategies and how we can use the same techniques to enhance our own discovery, capacity and wellbeing as clinicians.

THE GUESTS

Three of the world's pain superstars join Lorimer Moseley to discuss the future of pain care.

Mark Hutchinson - on the fundamental science, how cellular and molecular evidence can change the pain experience and what is just over the horizon in terms of technologies and our understanding of persistent pain.

Tasha Stanton - on understanding why people have pain and why sometimes it doesn't go away, looking at how we can treat osteo-arthritis in better and new ways.

David Butler - on education, vaccinations, conspiracy theories and how hard it is to change people's beliefs.
World leading scientists, pioneering researchers and leaders in pain care. What a line up!

You will:

Massively increase your knowledge of pain biology

Improve your ability to integrate this into your assessment and management of anyone in pain

Gain an insight into the future of pain research, science and care

Learn from some of the brightest minds in pain science in the world today

Course Enquiry

MasterSession with Lorimer Moseley, AU, US & CA Timezones, Broadcast 2 in Adelaide on

Contact Course Host

Instructors

Guest Lecturer

English, Australia

Courses: MasterSessions, EP3

Lorimer Moseley

Lorimer is Professor of Clinical Neurosciences and Foundation Chair in Physiotherapy at the University of South Australia. He has over 25 years clinical experience working with people in persistent pain, has authored hundreds of articles, multiple books and chapters and continues to present keynote lectures globally. His community outreach and whole of community education initiatives are internationally renowned. His work is cited in clinical guidelines internationally. He is an honoured member of the Australian Physiotherapy Association, an Honorary Fellow of the ANZCA Faculty of Pain Medicine and a Fellow of the Australian Academy of Health and Medical Sciences.

# data[].attributes.attachment_link.title
MasterSession with Lorimer Moseley, AU, US & CA Timezones, Broadcast 2 - Noigroup

# data[].attributes.attachment_link.description
Online Course LIVE | INTERACTIVE | GLOBAL Join Lorimer Moseley and his guests for this first ever global Pain MasterSession - a massive 16.5 hours of cutting-edge pain science and clinical application with 4 of the world's pain super stars. It's going to be incredible!

# data[].attributes.headline
Follow the BiM and Comms team on twitter to stay in touch

# data[].attributes.subject
Follow the BiM and Comms team on twitter to stay in touch

# data[].attributes.body
Anna Vogelzang - @anna_vogelzang

Erica Wilkinson - @wilkerica_

Brendan Mouatt – @BrendanMouatt

Tasha Stanton - @Tash_Stanton

Felicity Braithwaite - @dr_flick_

Erin MacIntyre - @erinmacintyre5

Sarah Wallwork -@SarahBWallwork

Caitlin Howlett - @caitlinahowlett

Brian Pulling - @BrianPulling

Millie Mardon - @Millie_Mardon

Emma Karran - @Emmakarran

Jane Chalmers – KjaneChalmers

Ash Grant - @ashley_grant5

Calie Altman - @carliealtmann

Hayley Leake - @hayleyleake

# data[].attributes.attachment_link.provider_name
RELIEF: PAIN RESEARCH NEWS, INSIGHTS AND IDEAS

# data[].attributes.attachment_link.title
Body In Mind Archives - RELIEF: PAIN RESEARCH NEWS, INSIGHTS AND IDEAS

# data[].attributes.attachment_link.description
For decades we have known that treatment outcomes for people with low back pain have been suboptimal. The research community has been trying to determine subgroups, based upon key individual characteristics, amongst those with low ...

# data[].attributes.headline
UniSA Professional Certificate in Pain Sciences

# data[].attributes.subject
UniSA Professional Certificate in Pain Sciences

# data[].attributes.body
https://study.unisa.edu.au/short-courses/professional-certificate-in-pain-sciences/

# data[].attributes.headline
Two of the most incredible minds exploring so many juicy ideas!

# data[].attributes.subject
Two of the most incredible minds exploring so many juicy ideas!

# data[].attributes.attachment_link.title
Learning How to Learn: Powerful mental tools to help you master tough subjects

# data[].attributes.attachment_link.description
Offered by Deep Teaching Solutions. This course gives you easy access to the invaluable learning techniques used by experts in art, music, ... Enroll for free.

# data[].attributes.headline
Self-Regulated Learning: Beliefs, Techniques, and Illusions

# data[].attributes.subject
Self-Regulated Learning: Beliefs, Techniques, and Illusions

# data[].attributes.body
As discussed by Dave and Loz on the couch!

# data[].attributes.body
"This Masterclass has been so worth getting up for! I've thoroughly enjoyed my peaceful mornings with my puppy before the rest of the house wakes up - and then sharing all this amazing information with my family. Learning, practicing, encoding!!" - Nicole

# data[].attributes.attachment_link.title
Explain Pain Second Edition Audiobook - Noigroup

# data[].attributes.attachment_link.description
Format = MP3 | Size = 266MB Download to desktop or laptop first before transferring to a mobile device The authors, David and Lorimer, personally...

# data[].attributes.headline
UniSA short course: Professional certificate in pain sciences (closing in three days)

# data[].attributes.subject
UniSA short course: Professional certificate in pain sciences (closing in three days)

# data[].attributes.body
https://study.unisa.edu.au/short-courses/professional-certificate-in-pain-sciences/

# data[].attributes.headline
References for Day 3 Session 5: Dave Butler

# data[].attributes.subject
References for Day 3 Session 5: Dave Butler

# data[].attributes.headline
Sticking with the theme - all pain scientists have a dress code - Dr Felicity Braithwaite

# data[].attributes.subject
Sticking with the theme - all pain scientists have a dress code - Dr Felicity Braithwaite

# data[].attributes.body
Tools, slogans & the importance of pondering on pictures

# data[].attributes.body
8. Retrain your pain system

# data[].attributes.headline
All Target Concepts are on the Pain Rev website too! Great resource!

# data[].attributes.subject
All Target Concepts are on the Pain Rev website too! Great resource!

# data[].attributes.headline
Learned immunosuppressive placebo responses in renal transplant patients

# data[].attributes.subject
Learned immunosuppressive placebo responses in renal transplant patients

# data[].attributes.attachment_link.readable_text
Significance

Akin to other physiological responses, immune functions can be modified in humans through associative conditioning procedures as part of a learned placebo response. However, it is unclear whether learned immune responses can be produced in patient populations already receiving an immunosuppressive regimen. In the present study, we demonstrate in renal transplant patients who were already receiving immunosuppressive treatment that learned immunosuppressive placebo responses increased efficacy of immunosuppressive medication. These data demonstrate that behavioral conditioning of drug responses may be a promising tool that could be used as a placebo-based dose-reduction strategy in an ongoing immunopharmacological regimen, the aim being to limit unwanted drug adverse effects and to improve treatment efficacy.

Abstract

Patients after organ transplantation or with chronic, inflammatory autoimmune diseases require lifelong treatment with immunosuppressive drugs, which have toxic adverse effects. Recent insight into the neurobiology of placebo responses shows that associative conditioning procedures can be employed as placebo-induced dose reduction strategies in an immunopharmacological regimen. However, it is unclear whether learned immune responses can be produced in patient populations already receiving an immunosuppressive regimen. Thus, 30 renal transplant patients underwent a taste-immune conditioning paradigm, in which immunosuppressive drugs (unconditioned stimulus) were paired with a gustatory stimulus [conditioned stimulus (CS)] during the learning phase. During evocation phase, after patients were reexposed to the CS, T cell proliferative capacity was significantly reduced in comparison with the baseline kinetics of T cell functions under routine drug intake (ƞ p ² = 0.34). These data demonstrate, proof-of-concept, that learned immunosuppressive placebo responses can be used as a supportive, placebo-based, dose-reduction strategy to improve treatment efficacy in an ongoing immunopharmacological regimen.

Results

Discussion

After organ transplantation or chronic inflammatory autoimmune diseases, patients depend on immunosuppressive medication for the rest of their lives, which can cause severe adverse effects. In this study with kidney transplant patients, long-term treated with immunosuppressive drugs cyclosporine A or tacrolimus, the introduction of a taste-immune conditioning procedure induced a significant learned inhibition of T cell proliferative capacity. The conditioning paradigm increased the effectiveness of the medications without any increase in medication dose. These data provide a proof of concept that learned placebo responses in immune functions can be employed as additional therapy during immunosuppressive treatment to maximize treatment efficacy.

The phenomenon of learned immune responses is based on two phenomena: On the one hand, it depends on the intense bidirectional communication between the CNS and the immune system ( 20, 25), and on the other hand, it relies on the ability of an organism to "learn" a physiological reflex via associative learning processes (classical or behavioral conditioning) ( 26, 27). Experimental evidence in rodents and healthy human subjects has demonstrated behaviorally conditioned immunosuppressive effects, both in humoral and cellular immune functions ( 4, 28). Employing the calcineurin-inhibitor CsA as an unconditioned stimulus in a taste-immune learning paradigm, we explored this phenomenon of learned immunosuppression as part of a conditioning-induced placebo response in healthy male subjects. These studies demonstrate that the learned immune response, reflected by inhibition of cytokine production, can be reproduced during a second, unreinforced reexposure to the CS ( 19); that the learned immune response can be induced by associative learning solely, and not via patient expectations ( 8, 29); and that extinction of the learned immunosuppressive response can be inhibited when subtherapeutic dosages of the immunosuppressant drug are applied together with the CS during prolonged evocation ( 12, 15).

Previous experimental data in rodents and healthy subjects supported the notion that classical conditioning of immunosuppressive drug responses is a promising tool that could be used to improve treatment outcomes. For example, evidence in rodents indicated that pretreatment with immunosuppressive drugs seems not to affect conditioned immune functions ( 30). However, the question arose of whether and to what extent patients already receiving long-term immunosuppressive therapy with calcineurin inhibitors such as CsA of tacrolimus (Tac) could still develop a learned immunosuppression. The data provided here demonstrate that implementing a taste-immune learning protocol into an unchanged drug regimen in long-term immunosuppressed renal transplant patients resulted in a learned immunosuppression reflected by an inhibition of T cell activity.

The potential clinical applicability of learned immunosuppressive responses has been convincingly demonstrated in rodents, where conditioned immune responses significantly reduced mortality in animals with inflammatory autoimmune disease and significantly reduced allergic responses or prolonged the survival time of transplanted vascularized organs ( 26, 31⇓ ⇓ - 34). These learned immune responses in rodents, as well as in healthy human subjects, were induced in the absence of any drug application or significantly reduced drug dosages administered during the evocation trials ( 4). These data suggest that learned immune responses may have a role as supportive therapy into an immunosuppressive regimen to maximize treatment efficacy and significantly decrease drug dosages, with the aim of reducing unwanted drug adverse effects ( 1). Furthermore, the toxic adverse effects of immunosuppressive substances such as calcineurin inhibitors (cardiovascular morbidity, nephrotoxicity, neurotoxicity, and hypertension) are predominantly caused by the pharmacological substance itself ( 21, 24). The behavioral conditioned immunosuppression exploits the brain-immune communication with significantly reduced drug dosages. We do not have yet direct evidence for potential reduction of long-term toxic drug adverse effects. However, we do know that the learned immunosuppression with CsA is diminishing the calcineurin activity, and that this effect seemed to be mediated via adrenoreceptors and distinct intracellular mechanisms compared with the drug effect ( 35, 36).

The precise mechanisms steering these learned placebo responses in immune functions in immunosuppressed patients are unclear. The learned immunosuppressive changes were neither associated with significant changes in cytokine mRNA expression, T lymphocyte numbers, plasma levels of cortisol, or catecholamines, nor associated with changes in cardiovascular or behavioral measures. In rodents, the conditioned immunosuppressive effects using CsA as an unconditioned stimulus are centrally mediated in the CNS via the insular cortex and the amygdala ( 37). In the periphery, the learned inhibition of calcineurin activity in lymphocytes seemed to be mainly mediated via noradrenergic innervation of lymphatic organs such as the spleen and β-adrenoreceptor-dependent mechanisms ( 9, 35, 36, 38). In addition, noradrenaline plasma levels were significantly correlated with the learned suppression of interleukin-2 levels in healthy volunteers ( 39). However, we could not identify any correlation between the learned T cell responses and sympathetic adrenal activity in the patient data presented here. In addition, patients receiving β-adrenoreceptor antagonists ( n = 20) did not significantly differ in their learned T cell response from patients taking no β-blockers ( n = 10). Further studies have to analyze the mechanisms mediating the learned immune responses in immunosuppressed patients.

The present study demonstrates the proof of principle that learned immunosuppressive placebo responses can be introduced into an ongoing immunosuppressive pharmacological regimen in renal transplant patients. There are a number of limitations, however, regarding possible clinical applicability of such learning strategies in clinical routine. The results of this study need to be replicated with a larger number of transplant patients over a longer period of time. Future studies have to examine whether these results also apply to patients with different requirements of long-term immunosuppressive therapy, such as chronic, inflammatory autoimmune diseases. In this context, it needs to be determined whether and to what extent the taste cues are essential in this learning paradigm to induce learned immunosuppressive effects. In healthy humans, extinction of the learned immunosuppressive response could be prevented by administering low therapeutic dosages of the drug together with the CS, inducing a reconsolidation process in the immune response ( 12, 15). In addition, inhibition of T cell proliferation or cytokine mRNA expression in lymphocyte are indicators of an immunosuppressive response; whether and to what extent this is also a corresponding marker for disease activity or the rejection process of transplanted organs has to be determined.

In general, analyzing long-term drug intake from the perspective of associative learning processes, behavioral conditioning of drug responses may be a promising tool that could be used as a placebo-based dose reduction strategy to limit unwanted drug adverse effects and to improve treatment efficacy ( 11, 14, 16, 17). For immunosuppressive regimens in particular, there is a need to understand which properties of which immunopharmacological agents can be behaviorally conditioned and which reinforcement schedules should be used to achieve optimal effects and prevent habituation or extinction of the learned immunopharmacological responses.

In summary, the clinical exploitation of learned placebo responses in immune functions is still in a very early stage. The data presented here provide experimental evidence that learned immunopharmacological responses can be implemented into ongoing immunosuppressive therapy in renal transplant patients.

Methods

Acknowledgments

We thank Alexandra Kornowski, Christa Freundlieb, Chris Hemond, and Magdalene Vogelsang for their technical assistance and their skilled help; and Dr. Harald Engler for reading earlier versions of this manuscript. This work was supported by German Research Foundation Grant FOR 1328; SCHE 341/17-2 and the Foundation of the Science of the Therapeutic Encounter.

Footnotes

Author contributions: O.W. and M.S. designed research; J.K., L.P., A.B., J.S., M.U., B.W., O.W., and M.S. performed research; J.K., L.P., S.B., J.S., M.U., B.W., T.J.K., and M.S. analyzed data; and S.B., T.J.K., O.W., and M.S. wrote the paper.

The authors declare no conflict of interest.

This article is a PNAS Direct Submission.

This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1720548115/-/DCSupplemental.

# data[].attributes.attachment_link.title
Learned immunosuppressive placebo responses in renal transplant patients

# data[].attributes.attachment_link.description
Akin to other physiological responses, immune functions can be modified in humans through associative conditioning procedures as part of a learned placebo response. However, it is unclear whether learned immune responses can be produced in patient populations already receiving an immunosuppressive regimen.

# data[].attributes.headline
Enhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes

# data[].attributes.subject
Enhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes

# data[].attributes.attachment_link.readable_text
Highlights

*

Placebo and nocebo represent complex and distinct psychoneurobiological phenomena.

*

The psychosocial context around the patient can influence the therapeutic outcome.

*

Every healthcare intervention is formed by a therapy specific and a context related component.

*

The contextual elements interact modulating the specific effect of the therapy.

*

To achieve the best therapeutic outcome it is useful to boost the context, the therapeutic relationship, the healing ritual.

Abstract

Introduction

Placebo and nocebo represent complex and distinct psychoneurobiological phenomena in which behavioural and neurophysiological modifications occur together with the application of a treatment. Despite a better understanding of this topic in the medical field, little is known about their role in physiotherapy.

Purpose

The aim of this review is: a) to elucidate the neurobiology behind placebo and nocebo effects, b) to describe the role of the contextual factors as modulators of the clinical outcomes in rehabilitation and c) to provide clinical and research guidelines on their uses.

Implications

The physiotherapist's features, the patient's features, the patient-physiotherapist relationship, the characteristics of the treatment and the overall healthcare setting are all contextual factors influencing clinical outcomes. Since every physiotherapy treatment determines a specific and a contextual effect, physiotherapists should manage the contextual factors as a boosting element of any manual therapy to improve placebo effects and avoid detrimental nocebo effects.

View full text

# data[].attributes.attachment_link.title
Enhance placebo, avoid nocebo: How contextual factors affect physiotherapy outcomes

# data[].attributes.attachment_link.description
Placebo and nocebo represent complex and distinct psychoneurobiological phenomena. * The psychosocial context around the patient can influence the therapeutic outcome. * Every healthcare intervention is formed by a therapy specific and a context related component. * The contextual elements interact modulating the specific effect of the therapy.

# data[].attributes.body
https://www.sciencedirect.com/science/article/abs/pii/S152659001830765X

# data[].attributes.headline
Publications from the amazing Felicity Braithwaite!

# data[].attributes.subject
Publications from the amazing Felicity Braithwaite!

# data[].attributes.attachment_link.title
TEDxAdelaide - Lorimer Moseley - Why Things Hurt

# data[].attributes.headline
References for Day 3 Session 2: Loz - The story of the four cornerstone concepts

# data[].attributes.subject
References for Day 3 Session 2: Loz - The story of the four cornerstone concepts

# data[].attributes.headline
Using visual illusion to reduce at-level neuropathic pain in paraplegia

# data[].attributes.subject
Using visual illusion to reduce at-level neuropathic pain in paraplegia

# data[].attributes.attachment_link.readable_text
Abstract

Neuropathic pain after spinal cord injury is not well understood and is difficult to treat. One possible cause is mismatch between motor commands and sensory feedback. This two-part study in five paraplegic patients investigated whether a visual illusion aimed to correct this mismatch reduces pain. In study 1, patients undertook three conditions: (i) virtual walking: with a mirror placed in front of a screen, patients aligned their own upper body with a film of a lower body walking. Patients imagined walking and 'watched themselves' walk; (ii) guided imagery; (iii) watching a film. One patient withdrew from virtual walking because of distress. For all patients, the mean (95% CI) decrease in pain (100 mm VAS) was 42 mm (∼65%) (11-73 mm) for virtual walking, 18 mm (4-31 mm) for guided imagery and 4 mm (−3 to 11 mm) for watching the film. Mean (95% CI) time to return to pre-task pain was 34.9 min (20.1-49.8 min) for virtual walking; 13.9 min (−0.9 to 28.8 min) for the guided imagery and 16.3 min (1.5-31.2 min) for the film. To investigate its clinical utility, four patients underwent virtual walking every weekday for 3 weeks. Mean (95% CI) decrease in pain was 53 mm (45-61 mm) at post training and 43 mm (27-58 mm) at 3-month follow-up. Virtual walking may be a viable treatment for pain after spinal cord injury. A clinical trial seems warranted.

View full text

# data[].attributes.attachment_link.title
Using visual illusion to reduce at-level neuropathic pain in paraplegia

# data[].attributes.attachment_link.description
Neuropathic pain after spinal cord injury is not well understood and is difficult to treat. One possible cause is mismatch between motor commands and sensory feedback. This two-part study in five paraplegic patients investigated whether a visual illusion aimed to correct this mismatch reduces pain.

# data[].attributes.body
Opioid-induced hyperalgesia (OIH) is defined as a state of nociceptive sensitization caused by exposure to opioids. The condition is characterized by a paradoxical response whereby a patient receiving opioids for the treatment of pain could actually become more sensitive to certain painful stimuli.

# data[].attributes.attachment_link.title
Toll-like receptors in chronic pain_ Nicotra et al

# data[].attributes.attachment_link.title
Beyond Desire_ Agency, Choice, and the Predictive Mind clark2019

# data[].attributes.attachment_link.title
Glial contributions to visceral pain_ implications for disease etiology and the female predominance of persistent pain

# data[].attributes.headline
The -Amps that increase synaptic efficacy of nociceptive neurotags

# data[].attributes.subject
The -Amps that increase synaptic efficacy of nociceptive neurotags

# data[].attributes.body
Damps (damage-Associated Molecular Patterns),

Pamps (Pathogen-Associated Molecular Patterns)

Xamps (Xenobiotic-Associated Molecular Patterns)

Camps (Cognition-Associated Molecular Patterns)

Bamps (Behaviour-Associated Molecular Patterns)

# data[].attributes.headline
References from Day 3 Session 1: Loz - Linking pain, neuroimmunology, and learning

# data[].attributes.subject
References from Day 3 Session 1: Loz - Linking pain, neuroimmunology, and learning

# data[].attributes.body
Session 1

Persistent pain and immune function

The AMP gang

Priming

More on The Three Musketeers

Session 2

Multiple strategies to reduce pain and promote recovery

First stop: skills and knowledge

Target concept development

Training the body and brain

Movement and loading, inflammation

Learning to learn

Session 3

Lorimer Moseley in discussion with Felicity Braithwaite

What can magicians teach clinicians?

Untangling pain with inquiry

Session 4

The tools we use

The Protectometer, DIMs and SIMs

Structure for pain education

Consumer cornerstone concepts

The amplifier

Session 5

Presentation from David Butler

The forgotten branch of educational psychology

Changing beliefs can be tough

Session 6

David Butler and Lorimer Moseley take a deep dive into pain education

Taking on the learn to learn before you learn revolution

Session 7

Ask Us Anything

Questions from the audience for Lorimer and David on anything from across the day

# data[].attributes.body
Aafke and Deike - We think that "graded exposure" might have a great influence for patients on prediction errors.

In my experience I tried "graded exposure" with some patients in the past. I only didn't get good results with it. Is there anything published you could share about graded exposure on the padlet? It might be a link to a book, a pdf or some information on a website.

# data[].attributes.body
Some papers that are mentioned

# data[].attributes.headline
An fMRI study measuring analgesia enhanced by religion as a belief system

# data[].attributes.subject
An fMRI study measuring analgesia enhanced by religion as a belief system

# data[].attributes.attachment_link.readable_text
Abstract

Although religious belief is often claimed to help with physical ailments including pain, it is unclear what psychological and neural mechanisms underlie the influence of religious belief on pain. By analogy to other top-down processes of pain modulation we hypothesized that religious belief helps believers reinterpret the emotional significance of pain, leading to emotional detachment from it. Recent findings on emotion regulation support a role for the right ventrolateral prefrontal cortex (VLPFC), a region also important for driving top-down pain inhibitory circuits. Using functional magnetic resonance imaging in practicing Catholics and avowed atheists and agnostics during painful stimulation, here we show the existence of a context-dependent form of analgesia that was triggered by the presentation of an image with a religious content but not by the presentation of a non-religious image. As confirmed by behavioral data, contemplation of the religious image enabled the religious group to detach themselves from the experience of pain. Critically, this context-dependent modulation of pain specifically engaged the right VLPFC, whereas group-specific preferential liking of one of the pictures was associated with activation in the ventral midbrain. We suggest that religious belief might provide a framework that allows individuals to engage known pain-regulatory brain processes.

View full text

# data[].attributes.attachment_link.title
An fMRI study measuring analgesia enhanced by religion as a belief system

# data[].attributes.attachment_link.description
Although religious belief is often claimed to help with physical ailments including pain, it is unclear what psychological and neural mechanisms underlie the influence of religious belief on pain. By analogy to other top-down processes of pain modulation we hypothesized that religious belief helps believers reinterpret the emotional significance of pain, leading to emotional detachment from it.

# data[].attributes.headline
Mark Hutchinson's "Covid19 Plan" on keeping well using science!

# data[].attributes.subject
Mark Hutchinson's "Covid19 Plan" on keeping well using science!

# data[].attributes.body
https://docs.google.com/document/d/103xnNiwBePxVEOnsMJPPivgvMXFxX6dNwd7W9SfNKLs/edit

# data[].attributes.headline
Mark Hutchinson's publications and book chapters can be found here:

# data[].attributes.subject
Mark Hutchinson's publications and book chapters can be found here:

# data[].attributes.attachment_link.readable_text
Adelaide Medical School

Mark's research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments.

Mark has published over 170 papers in journals and refereed conference proceedings.

The CNBP is an ARC Centre of Excellence with $38M of funding committed for 7 years, headquartered at The University of Adelaide, with nodes at Macquarie University, Sydney; the RMIT, Melbourne; and Griffith University, the Gold Coast. We are partnered with universities and companies in Europe, the US and China, as well as other Australian institutions.

The CNBP has a mission to "Discover new approaches to measure nano-scale dynamic phenomena in living systems".
I have several openings for research projects within my team for PhD students

Expand
Journals

2021

Ribarovska, A. K., Hutchinson, M. R., Pittman, Q. J., Pariante, C., & Spencer, S. J. (2021). Gender inequality in publishing during the COVID-19 pandemic. Brain, Behavior, and Immunity, 91, 1-3.
DOI Scopus1

2021

Zhang, T., Zhang, X., Lin, C., Wu, S., Wang, F., Wang, H., . . . Wang, X. (2021). Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood-brain barrier leakage in mice. Journal of Neurochemistry, 157(3), 611-623.
DOI Scopus1

2020

Deng, F., Arman, A., Goldys, E. M., Hutchinson, M. R., & Liu, G. (2020). A Method for in Vivo Quantification of Cytokine IL-1β in the Rat Intrathecal Space. ACS Applied Bio Materials, 3(1), 539-546.
DOI Scopus2

2019

Liu, G., Bursill, C., Cartland, S. P., Anwer, A. G., Parker, L. M., Zhang, K., . . . Goldys, E. M. (2019). A Nanoparticle-Based Affinity Sensor that Identifies and Selects Highly Cytokine-Secreting Cells. iScience, 20, 137-147.
DOI Scopus5 WoS5

2018

Hutchinson, M. R., Stoddart, P. R., & Mahadevan-Jansen, A. (2018). Challenges and opportunities in neurophotonics discussed at the International Conference on Biophotonics 2017. Neurophotonics, 5(4), 1-5.
DOI Scopus4 WoS3

2018

Hutchinson, M. R. (2018). GLIA AND PAIN. SCIENTIST, 32(1), 34-41.

2018

Hutchinson, M. R. (2018). Glial ties to persistent pain : Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain. Scientist, 32(1), 34-41.

2014

DOI Scopus2

2013

Thomas, J., & Hutchinson, M. R. (2013). Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids (vol 12, pg 1311, 2012). EXPERT REVIEW OF NEUROTHERAPEUTICS, 13(3), 339-340.

Datasets

Figures

I regularly teach into continuing medical education courses for Medical Colleges, Faculties and Societies.

I also teach into several University of Adelaide undergraduate courses as an invited specialist lecturer

Expand
Board Memberships

Date

Role

Board name

Institution name

Country

2013 - ongoing

Board Member

Science Technology Australia

-

Australia

Memberships

Date

Role

Membership

Country

Editorial Boards

Date

Role

Editorial Board Name

Institution

Country

2015 - ongoing

Associate Editor

Brain, Behavior, and Immunity

-

-

# data[].attributes.attachment_link.description
Adelaide Medical School Mark's research has implicated the brain immune-like cells in the action of drugs of dependence and the negative side effects of pain treatments. Mark has published over 170 papers in journals and refereed conference proceedings.

# data[].attributes.headline
You can contact Mark through the email address and twitter handles here:

# data[].attributes.subject
You can contact Mark through the email address and twitter handles here:

# data[].attributes.body
A lot of potential targets for pharma therapy revealed recently

# data[].attributes.headline
Is endometriosis a disease OF Lesions or a disease associated with lesions?

# data[].attributes.subject
Is endometriosis a disease OF Lesions or a disease associated with lesions?

# data[].attributes.headline
Pharma is only limited on  targeting mechanisms that underpin pain

# data[].attributes.subject
Pharma is only limited on  targeting mechanisms that underpin pain

# data[].attributes.headline
3 ways of connections between immunolgy and the brain

# data[].attributes.subject
3 ways of connections between immunolgy and the brain

# data[].attributes.headline
From Thacker and Mansfield 'Staring down the barrel of a gun..." on neuroimmune intercations pain and COVID 

# data[].attributes.subject
From Thacker and Mansfield 'Staring down the barrel of a gun..." on neuroimmune intercations pain and COVID 

# data[].attributes.attachment_link.readable_text
No References for this article.

Document Type: Editorial

Publication date: 01 July 2020

More about this publication?

Pain and Rehabilitation is a peer-reviewed, Bi-annual journal of the Physiotherapy Pain Association and special interest group of the Chartered Society of Physiotherapy. The journal comprises a range of different articles types from orignial articles to systematic reviews and letters around the topic of pain and rehabilitation. The journal is multidisciplinary in its focus and welcomes submissions from all professionals working in this multidisciplinary field. the abstract of all articles will be freely avilable online. Full text articles are available free online to members of the Physiotherapy Pain Association, and access to individual PDF articles can be purchased by non members.

# data[].attributes.attachment_link.title
Staring Down the Barrel of a Gun: A Potential Pain Pandemic Follo...: Ingenta Connect

# data[].attributes.attachment_link.description
No References for this article. Document Type: Editorial Publication date: 01 July 2020 More about this publication? Pain and Rehabilitation is a peer-reviewed, Bi-annual journal of the Physiotherapy Pain Association and special interest group of the Chartered Society of Physiotherapy.

# data[].attributes.headline
3 ways of connetion betwenn immunology and the brain

# data[].attributes.subject
3 ways of connetion betwenn immunology and the brain

# data[].attributes.body
Von Hehn et al., 2012

# data[].attributes.headline
Biology is not linear - Where do you fit on that line? 

# data[].attributes.subject
Biology is not linear - Where do you fit on that line? 

# data[].attributes.headline
References from Day 2 Session 4: Mark Hutchinson 'Pain in 4D'

# data[].attributes.subject
References from Day 2 Session 4: Mark Hutchinson 'Pain in 4D'

# data[].attributes.body
How does these five relate to each other?

# data[].attributes.body
Relevant links will appear below