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good idea: chromosomes as background and arrows as connection
well explained

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-no cure, only symptomatic treatment

-growth hormone therapy for Turner syndrome

-educational and behavioral therapy for Down syndrome

-palliative care for Edwards syndrome

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https://www.sciencedirect.com/topics/medicine-and-dentistry/aneuploidy;
https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=90&contentid=p02356;
https://ist.ac.at/en/news/congratulations-to-angelika-amon-member-of-the-scientific-board-of-ist-austria-for-winning-the-2019-breakthrough-prize/;
https://www.webmd.com/baby/what-is-trisomy-18;
https://www.mayoclinic.org/diseases-conditions/turner-syndrome/symptoms-causes/syc-20360782

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-Down syndrome (Trisomy 21)

-Edwards syndrome (Trisomy 18)

-Turner syndrome (45, X)

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Monosomy: one chromosome missing

Disomy: normal number of chromosomes

Trisomy: extra chromosome

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A single organism possesses more than one genetic line as the result of genetic mutation.

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The failure of chromosomes to disjoin normally during meiosis

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The Breakthrough Prize in Life Sciences

- largest award in science
- given to researchers who have made discoveries that extend human life
- worth 3 Million Dollars

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-most common type of human chromosome abnormality

-occurs in 3-4% of (clinically recognised) pregnancies

-abnormal chromosome number

-extra gonosomes more tolerable than autosomes

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Breakthrough Prize in Life Sciences 2019

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Breakthrough Prize in Life Sciences 2019

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Won the Breakthrough Prize in Life Sciences in 2019

Recognizing her research determining the consequences of aneuploidy

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- member of Austrian Scientific Board

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Main reason:
-maternal nondisjunction during meiosis

More rarely:
-chromosomal dislocation

-mosaicism

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Austrian molecular and cell biologist

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born and studied in Vienna
eventually ended up as professor at the MIT in cancer research

Research field:

how chromosomes are regulated, duplicated, and partitioned in the cell cycle