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Animals are the most common carriers of the bacterial infection E. coli, but it does not cause illness in animals. It can only cause illness in humans.

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Escherichia coli is the most frequent cause of many common bacterial infections such as cholangitis, urinary tract infection, bactermia, cholecystitis, and traveler's diarrhea. A few other infections caused by E. coli are neonatal meningitis and pneumonia.