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•Opportunistic human pathogen

•Source of infection is most likely the environment

•Environmental organism that causes three disease syndromes in humans

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What are some Pharmacokinetics of Drugs Used for Mycobacterium Avium Complex?

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What are some Pharmacokinetics of Drugs Used for Mycobacterium Avium Complex?

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•Antibacterial Agents

•Antimicrobials such as Vancomycin or the Aminoglycoside class of agents

•Macrolides and Azalides

•Rifamycins/Clofazimine/Ethambutol/Quinolones/Aminoglycosides/Liposomal AMGs/Aminosidine

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How is Someone Tested for Mycobacterium Avium Complex?

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How is Someone Tested for Mycobacterium Avium Complex?

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•MAC Serovars to Indicate MAC colonolization probably relates to environmental exposure

•MAC Plasmids

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How is Mycobacterium Avium Complex Spread?

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How is Mycobacterium Avium Complex Spread?

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•Wild birds

•Water & Aerosols

•Amphibians and Mammals other than humans

•Soil

•Food

•Humans

•insects

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What are some Therapeutic Agents for Mycobacterium Avium Complex?

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What are some Therapeutic Agents for Mycobacterium Avium Complex?

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•Rifabutin

•Clofazimine

•Ethambutol

•Amikacin

•Azithromycin

•Paromomycin

•Clarithromycin

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How Widespread is Mycobacterium Avium Complex?

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How Widespread is Mycobacterium Avium Complex?

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•Survey from 1981-1983 – prevalence of the disease was 1.28 cases per 100,000 population

•More wide spread in coastal counties of North & South Carolina, Georgia, Florida, Alabama, Mississippi, Louisiana, and Texas

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What is the Disseminated  disease in AIDS that comes from Mycobacterium Avium Complex?

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What is the Disseminated  disease in AIDS that comes from Mycobacterium Avium Complex?

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•98% of cases are caused by M. Avium rather than M. intracellulare

•Opportunistic infection

•Non-tuberculosis mycobacterial infection

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What is the Pulmonary Disease Syndrome that comes from Mycobacterium Avium Complex?

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What is the Pulmonary Disease Syndrome that comes from Mycobacterium Avium Complex?

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•Due to organisms of the M. Avium Complex – pulmonary MAC

•Non-Tuberculosis mycobacteria

•Suspect that prior histoplasmosis facilitates MAC by causing parenchymal scarring with bronchiectasis or impaired d

•Can cause necrotizing inflammation drainage due to bronchial compromise

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What is Cervical Lymphadenitis, syndrome that comes from Mycobacterium Avium Complex?

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What is Cervical Lymphadenitis, syndrome that comes from Mycobacterium Avium Complex?

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•Common problem in children

•Transient response to a benign local or generalized infection

•Acute bilateral cervical lymphadenititis is usually caused by a viral upper respiratory tract infection or streptococcal pharyngitis

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What are the disease syndromes that come from Mycobacterium Avium Complex?

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What are the disease syndromes that come from Mycobacterium Avium Complex?

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•Cervical lymphadenitis

•Pulmonary disease

•Disseminated disease in AIDS

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What are the Symptoms of Mycobacterium Avium Complex?

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What are the Symptoms of Mycobacterium Avium Complex?

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•Shortness of breath.

•Fever.

•Sweating.

•Weight loss.

•Fatigue.

•Diarrhea.

•Abdominal pain.

•Anemia.

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Patient Teaching for Mycobacterium Avium Complex?

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Patient Teaching for Mycobacterium Avium Complex?

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•Incentive Spirometer

•Let patient know to take baths instead of showers

•Let patient know to not work in flowerbeds or dirt

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Prevention of Mycobacterium Avium Complex

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Prevention of Mycobacterium Avium Complex

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Staying away from sources of spread of bacteria in the environment