# data[].attributes.body
* Certain arteries in the brain are constricted
*The blood flow is blocked by constriction and blood clots (=thrombosis)
*To compensate for the blockage collateral vessels are built for circulation
*Collateral vessels are weak and easily cause bleeding, aneurysm and thrombosis
*Results in hemorrhagic stroke or seizure

# data[].attributes.body
*In MR angiography collateral vessels look like a "puff of smoke", similar to a cloud, which means "moyamoya" in Japanese
*Cerebral angiography is the standard method to diagnose and follow the progression of the disease

# data[].attributes.body
*Blood leaks out of the arteries, which causes pressure on the brain, leading to headaches and progressing to cognitive disabilities
*10% of the cases are familial
*Different variations of Moyamoya disease are caused by genetic mutations on different chromosomes and genes
*The pathogenesis is so far unknown, although RNF213 has been implicated

# data[].attributes.body
*In 2020 the IMP (Research Institute Of Molecular Pathology located at the Vienna Biocenter) published their breakthrough on the pathogenesis of the Moyamoya disease
*"Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and  distinct ubiquitin-transfer mechanism"
(https://pubmed.ncbi.nlm.nih.gov/32573437/)

# data[].attributes.body
1. https://pubmed.ncbi.nlm.nih.gov/32573437/ by
Ahel, J., Lehner, A., Vogel, A., Schleiffer, A., Meinhart, A., Haselbach, D., Clausen, T. (2020)

2. https://www.bcm.edu/healthcare/specialties/neurosurgery/cerebrovascular-and-stroke-surgery/moyamoya-disease

3. https://en.wikipedia.org/wiki/Moyamoya_disease

4. https://www.mayoclinic.org/diseases-conditions/moyamoya-disease/symptoms-causes/syc-20355586