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Reducing Disparities in Access to Higher Education Resources in South Africa: A Multi-institutional Learning Collaborative and Measures Bank

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Reducing Disparities in Access to Higher Education Resources in South Africa: A Multi-institutional Learning Collaborative and Measures Bank

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Sustainable Academic Capacity Building of Excellence through Research and Training Program (SACERT)

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Sustainable Academic Capacity Building of Excellence through Research and Training Program (SACERT)

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CYFAM Conference 2025 Poster (Updated for UCLA BRI)

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Enhanced lipoprotein lipolysis by PPARα variant V227A drives plasma triglyceride reduction

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Enhanced lipoprotein lipolysis by PPARα variant V227A drives plasma triglyceride reduction

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Gabriel P. Ordonez¹, Lauren F. Uchiyama2,3, Khoi Pham¹, John P. Kennelly2,3, Lany D. Tran¹, Peter Tontonoz2,3, Alexander H. Nguyen¹

¹Vatche and Tamar Manoukian Division of Digestive Diseases - Department of Medicine

²Department of Pathology & Laboratory Medicine

³Department of Biological Chemistry

David Geffen School of Medicine, University of California, Los Angeles

Paper: https://doi.org/10.1016/j.jlr.2025.100806

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Authors: Rida Ismail, Akshata Kapadne, Christopher Giza and Kevin Bickart

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Sleep Impairment as an Independent Predictor of Persistent 

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Sleep Impairment as an Independent Predictor of Persistent 

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Post-Concussion Symptoms

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hPSC-Derived Blood-Brain Barrier Cellular Model Reveals Distinct Mechanisms of Old-World Alphavirus Neuroinvasion

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hPSC-Derived Blood-Brain Barrier Cellular Model Reveals Distinct Mechanisms of Old-World Alphavirus Neuroinvasion

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Pablo Alvarez, Ashley Tang, Declan M. Winters, Prashaant Kaushal, Angelica Medina, Karolina E. Kaczor-Urbanowicz, Bryan Ramirez Reyes, Robyn M. Kaake, Oliver I. Fregoso, Apryl D. Pyle, Mehdi Bouhaddou, Hengli Tang, Melody M.H. Li.

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B-cell Function Restored in X-Linked Agammaglobulinemia Immunodeficiency Through Correction of BTK with Adenine Base Editing

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B-cell Function Restored in X-Linked Agammaglobulinemia Immunodeficiency Through Correction of BTK with Adenine Base Editing

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Personalizing vaccination using complex mathematical models

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Personalizing vaccination using complex mathematical models

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Science is essential to continue at universities because it drives discovery, trains future innovators, and requires sustained funding through grants to advance knowledge and address society’s greatest challenges.

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poster Panagiota Kolitsida 2025 Keystone final

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Programmable Artificial RNA Condensates in Mammalian Cells

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Programmable Artificial RNA Condensates in Mammalian Cells

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Brainwide imaging of single neuron pathology in Alzheimer’s mouse model using BRAINInitiative technologies

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Brainwide imaging of single neuron pathology in Alzheimer’s mouse model using BRAINInitiative technologies

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C.Y. Daniel Lee1,2, Chang S. Park1,2, Masood Akram1,2, Amberlene J. De La Rocha1,2, Henry Y. Chen1,2, Karl Marrett³, Jason Cong³, Hong Wei Dong4,5, and X. William Yang1,2,5

¹Center for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior;

²Dept. of Psychiatry and Biobehavioral Science, David Geffen School of Medicine at UCLA, Los Angeles, CA.

³Department of Computer Science, UCLA, Los Angeles, CA 5 Brain Research Institute, UCLA, Los Angeles, CA

⁴Dept of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA

⁵Brain Research Institute, UCLA, Los Angeles, CA

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Targeting the DNA mismatch repair gene for mechanism-based therapy in Huntington's disease

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Targeting the DNA mismatch repair gene for mechanism-based therapy in Huntington's disease

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C.Y. Daniel Lee1,2, Linna Deng1,2, Nianxin Zhong1,2, Nan Wang1,2, Robert Damoiseaux⁴⁻⁵ and X. William Yang¹⁻³

¹Center for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior;

²Dept. of Psychiatry and Biobehavioral Science, David Geffen School of Medicine at UCLA, Los Angeles, CA.

³Brain Research Institute at UCLA, Los Angeles, CA.

⁴Dept. of Molecular and Medical Pharmacology, UCLA, Los Angeles, CA.

⁵California NanoSystems Institute at UCLA, Los Angeles, CA.

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Cue-evoked dopamine release in the nucleus accumbens core encodes reward prediction for strategy selection

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Cue-evoked dopamine release in the nucleus accumbens core encodes reward prediction for strategy selection

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Dopamine NAcc strategy selection reward seeking

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The Effects of Severe Traumatic Brain Injury on Glymphatic Flow 

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The Effects of Severe Traumatic Brain Injury on Glymphatic Flow 

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Brain connectivity of the awake, freely-moving mouse during activity and rest before and after repeat concussion using Functional Ultrasound Imaging

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Brain connectivity of the awake, freely-moving mouse during activity and rest before and after repeat concussion using Functional Ultrasound Imaging

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Multi-Site NeuroCombat Harmonization of Neuroimaging Data after Rat CCI Injury. 

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Multi-Site NeuroCombat Harmonization of Neuroimaging Data after Rat CCI Injury. 

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Vision Restoration - Robot-Assisted Microsurgery

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Vision Restoration - Robot-Assisted Microsurgery

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scRNA-seq analysis of the lung reveals chronic inflammation in mice with Osteogenesis Imperfecta

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scRNA-seq analysis of the lung reveals chronic inflammation in mice with Osteogenesis Imperfecta

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Characterizing the Functional Consequences of Zinc Finger Antiviral Protein (ZAP) RNA Binding

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Characterizing the Functional Consequences of Zinc Finger Antiviral Protein (ZAP) RNA Binding

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Traumatic Brain Injury: The Most Complex Injury to the Most Complex Organ - Yena Andreev, MSW

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Traumatic Brain Injury: The Most Complex Injury to the Most Complex Organ - Yena Andreev, MSW

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TBI Save Our Science BrainSPORT 20250907 CCG_YA_QR Coe 090825

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Autonomic Functioning: Overview, Assessment Approaches, and Relevance to Concussion Recovery in Youth - Aliyah Snyder, PhD, Anne Brown, Shriya Nayyar

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Autonomic Functioning: Overview, Assessment Approaches, and Relevance to Concussion Recovery in Youth - Aliyah Snyder, PhD, Anne Brown, Shriya Nayyar

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Memantine: From Dementia to Post-Traumatic Headache - Bradley Shane, MD

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Memantine: From Dementia to Post-Traumatic Headache - Bradley Shane, MD

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Review and Clinical Implementation of Current Guidelines for Consideration of Retirement from Contact Sport and Evaluation of Later-in-Life Risks Associated with Concussion and Repetitive Head Impacts - William Flavin MD, PhD

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Review and Clinical Implementation of Current Guidelines for Consideration of Retirement from Contact Sport and Evaluation of Later-in-Life Risks Associated with Concussion and Repetitive Head Impacts - William Flavin MD, PhD

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Visualizing PINK1 Activity Dynamics with a Phase Separation-Based Kinase Activity Reporter 

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Visualizing PINK1 Activity Dynamics with a Phase Separation-Based Kinase Activity Reporter 

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Visualizing PINK1 Activity Dynamics with a Phase Separation-Based Kinase Activity Reporter

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Impacts of Soluble Factors from Oligodendrocyte Progenitor Cells on Glioblastoma Cell Viability​

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Impacts of Soluble Factors from Oligodendrocyte Progenitor Cells on Glioblastoma Cell Viability​

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A cell-type specific molecular map of the cichlid hypothalamus

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A cell-type specific molecular map of the cichlid hypothalamus

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Small Molecule Enhancer of Secreted Clusterin Promotes Mitochondrial Function, Synaptic Plasticity and Improved Memory in an Alzheimer's Disease Mouse Model

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Small Molecule Enhancer of Secreted Clusterin Promotes Mitochondrial Function, Synaptic Plasticity and Improved Memory in an Alzheimer's Disease Mouse Model

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Secreted clusterin (sCLU), a protective isoform of the Alzheimer’s risk gene CLU, helps clear amyloid and tau, reduces oxidative stress, and modulates immunity. Our lab developed DDL-357, a brain-penetrant BET inhibitor that strongly boosts sCLU expression. In Alzheimer’s mouse models, DDL-357 improved memory, increased sCLU, and reduced phosphorylated tau. Proteomics showed activation of pathways for mitochondria, synaptic plasticity, and neuronal growth, with similar benefits seen in human iPSC-derived neurons. These results support sCLU enhancement by DDL-357 as a promising therapeutic strategy to protect synapses and slow dementia progression.

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Ants with ID Tags Reveal Nature's Supply Chain

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Ants with ID Tags Reveal Nature's Supply Chain

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Post-stroke injection of a porous hydrogel scaffold with nanoparticle-bound vascular endothelial growth factor encourages axonal sprouting and glial migration into the infarct

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Post-stroke injection of a porous hydrogel scaffold with nanoparticle-bound vascular endothelial growth factor encourages axonal sprouting and glial migration into the infarct

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Elle M. Rathbun, Sahith Doddipalli, Kevin Erning, Nhi V. Phan, Tatiana Segura, S. Thomas Carmichael

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In this work, we investigate how a particular type of neuron in the cortex, parvalbumin interneurons, regulate plasticity. We find that parvalbumin interneuron activity changes when sensory input changes and that changes in parvalbumin interneuron activity can dramatically affect the activity of other types of neurons in the cortex. We also found that after a stroke, parvalbumin interneuron activity is reduced. Our results suggest that targeting parvalbumin interneurons might be a therapeutic strategy for increasing plasticity in the brain after injury.

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Novel Highly Elastic, Suturable Biomaterial Development for the Lower Urinary Tract

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Novel Highly Elastic, Suturable Biomaterial Development for the Lower Urinary Tract

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In this work, we explore how pathology associated with Parkinson's disease contributes to dysfunction of cortical circuits and cognitive impairment. Our results help us understand the basis for cognitive impairments in Parkinson's disease, knowledge which is essential for developing treatments to treat, slow, or hopefully prevent dementia in Parkinson's disease.

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Multi-omics profiling of a vision-dependent neuronal continuum in the visual cortex

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Multi-omics profiling of a vision-dependent neuronal continuum in the visual cortex

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Please add your entry to our virtual program!

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Please add your entry to our virtual program!

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This is the virtual program for the Science Fair for Suspended Research! Please add the title of your presentation, the authors, and a brief description. The brief description can be in the form of text, an image (maybe your poster) or a short video (less than 100 megabytes, around 3 minutes). If you can't make it in person, you can still participate virtually by adding your research here! To add your entry, simply click on the plus sign in the black circle at the bottom right of this window!

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Stereotypes Are More Powerful When People Like to Agree with Each Other

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Stereotypes Are More Powerful When People Like to Agree with Each Other

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Michael Chwe, Political Science