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It has been discovered that Native populations had many nutritional deficiencies in their diets during the pre-Columbian era. One of the most common being anemia iron deficiency causing issues in cranial bones. This, among other diet insufficiencies, can cause a decrease in immune support and make populations more vulnerable to disease.

(Health Conditions, 2002)

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Health care in the Western world was not scientific in nature, but instead was ritualistic and religious. Their lack of scientific medicine allowed disease to spread easily and cause harm to those infected.

(Health Conditions, 2002)

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Native populations had not been exposed to the diseases that the Eastern world had dealt with for many centuries. Therefore, they did not have the genetic predisposition for immunity that the Europeans had to common Eastern ailments.

(Columbian Exchange, 165)

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The Eastern world carried many diseases with them on their voyages over to the Americas, such as smallpox, chickenpox, hepatitis, typhus, whooping cough, and others. These new infections took the Western world by storm, spreading quickly and killing easily.

(Columbian Exchange, 165)

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Population decline of up to 95% in the centuries after the introduction of Eastern peoples.

(Columbian Exchange, 165)

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Native Americans in the 15th-17th centuries.